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Volume 27, Number 3 (September)

Insulin Pens for Type 2 Diabetes (pages 6-12)

Mark Peyrot, Ph.D., and Richard R. Rubin, Ph.D.

Although insulin pens show potential for improving clinical and patient-reported outcomes, they are used by less than 20% of people who use insulin. This study used national samples of patients and physicians to examine how physicians and patients perceive pens, what factors are associated with pen-related physician-patient interactions, and how these factors are associated with patients’ initiation and use of pens.
EquipmentInsulin pens

How to Recognize and Manage Periodontal Disease in the Diabetic Patient (pages 14-16)

David J. Lasho, D.D.S., M.S.D.

Level of glycemic control plays a significant role as a risk factor for gingivitis and periodontitis. Conversely, as Dr. Lasho explains, periodontal therapy improves glycemic control. This article provides background information on periodontal disease, explains how to recognize the signs and symptoms, and includes general guidelines on management.
Complications and comorbiditiesTooth and gum complications

Syndromes of Extreme Insulin Resistance (pages 17-25)

Brian T. Allenbrand, M.D., Capt, USAF, MC, Mark K. Wallace, M.D., Maj, USA, MC, and Tom Sauerwein, M.D., LtCol, USAF, MC

A 31-year-old, thin, African-American female with a history of systemic lupus erythematosus was referred to endocrinology with presumed steroid-induced hyperglycemia. In this article, the authors describe this unusual case of extreme insulin resistance and review the pathophysiology, diagnosis, and treatment of the syndromes of severe insulin resistance.
Complications and comorbiditiesExtreme insulin resistance

Tight Glycemic Control and Cardiovascular Events (pages 26-27)

Charles A. Reasner, M.D.

At the American Diabetes Association Meeting in June, the findings of three large trials (ADVANCE, ACCORD, and VADT) were presented, each designed to assess the effect of glycemic control on macrovascular complications. All three studies failed to show a reduction in macrovascular end points. The Editor offers an interesting assessment of these results.
Complications and comorbiditiesCardiovascular disease